PURITY STUDIES ON POLYPEPTIDE ANTIBIOTICS: BACITRACIN 1
نویسندگان
چکیده
منابع مشابه
Bacitracin, Glycopeptide Antibiotics, and the Polymyxins
Bacitracin and the polymyxins are polypeptide antibiotics. They are relatively toxic drugs and have had only limited use in chemotherapy until recently. Vancomycin, a glycopeptide, although not without side effects, is widely used.Teicoplanin is a new glycopeptide antibiotic that may be beneficial against certain infections caused by gram-positive organisms. The mechanisms of action of this gro...
متن کاملBiosynthesis of polypeptide antibiotics.
Peptide antibiotics possess a variety of chemical structures, e.g. cyclic diand oligopeptides. depsipeptides, linear peptides with repeating sequences of Land D-amino acids, substituted peptides containing non-peptide components. These antibiotics frequently contain amino acids which are not constituents of proteins. In general, biosynthesis of peptide antibiotics follows active growth and macr...
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The structures of three polypeptide hormones (glucagon, a 25-residue analogue of adrenocorticotropin, and parathyroid hormone) which contain enough residues to permit organization have been evaluated in aqueous solution by fluorescence and circular dichroism. The effects of pH, temperature, and guanidine on both tyrosyl and tryptophanyl emission have been measured. None of the fluorescence para...
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We report structural studies in aqueous solution on backbone cyclic peptides that possess potent antimicrobial activity specifically against Pseudomonas sp. The peptides target the �-barrel outer membrane protein LptD, which plays an essential role in lipopolysaccharide transport to the outer membrane. The peptide L27-11 contains a 12-residue loop (T(1)W(2)L(3)K(4)K(5)R(6)R(7)W(8)K(9)K(10)A(11)...
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The discovery of gramicidin, penicillin, streptomycin, and the numerous other antibiotics known today has contributed materially to the list of therapeutic agents available against micro-organisms. However, the immediate enthusiasm which greeted their introduction has had to be checked by the realization that many of the important organisms affected readily develop resistance to the antibiotic ...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1949
ISSN: 0021-9738
DOI: 10.1172/jci102131